Publications

Karl Jordan, John D Kelleher, Aidan D Meade (2022). A MACHINE LEARNING CLASSIFICATION APPROACH TO PREDICT RADIOTHERAPEUTIC TOXICITY.. Phys. Med.,104,S32-S33, https://www.sciencedirect.com/science/article/abs/pii/S1120179722021901.

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Ciara Slattery, Khanh Nguyen, Laura Shields, Isabel Vega-Carrascal, Sean Singleton, Fiona M Lyng, Brendan McClean, Aidan D Meade (2022). Application of Advanced Non-Linear Spectral Decomposition and Regression Methods for Spectroscopic Analysis of Targeted and Non-Targeted Irradiation Effects in an In-Vitro Model. IJMS, https://www.mdpi.com/1422-0067/23/21/12986.

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Laura E Kane, Gregory S Mellotte, Eimear Mylod, Rebecca M O'Brien, Fiona O'Connell, Croí E Buckley, Jennifer Arlow, Khanh Nguyen, David Mockler, Aidan D Meade, Barbara M Ryan, Stephen G Maher (2022). Diagnostic accuracy of blood-based biomarkers for pancreatic cancer: A systematic review and meta-analysis. Can. Res. Comm., https://doi.org/10.1158/2767-9764.CRC-22-0190.

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Barbara Tanno, Flavia Novelli, Simona Leonardi, Caterina Merla, Gabriele Babini, Paola Giardullo, Munira Kadhim, Damien Traynor, Dinesh KR Medipally, Aidan D Meade, Fiona M Lyng, Soile Tapio, Luca Marchetti, Anna Saran, Simonetta Pazzaglia, Mariateresa Mancuso (2022). MiRNA-Mediated Fibrosis in the Out-of-Target Heart following Partial-Body Irradiation. Cancers, https://www.mdpi.com/2072-6694/14/14/3463.

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L.E. Kane, G.S. Mellotte, E. Mylod, R.O'Brien, F. O'Connell, K.Nguyen, C. E Buckley, J. Arlow, D. Mockler, A. D Meade, B.M. Ryan, S. G. Maher (2021). Diagnostic accuracy of blood-based multi-omic biomarkers for pancreatic adenocarcinoma: A systematic review and meta-analysis.. Can. Res.,81(22), 6-7, https://aacrjournals.org/cancerres/article/81/22_Supplement/PO-008/670388.

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O. Howe, L. White, D. Cullen, G. O’Brien, L. Shields, J. Bryant, E. Noone, S. Bradshaw, M. Finn, M. Dunne, A. M. Shannon, J. Armstrong, B. McClean, A. Meade, C. Badie, F. M. Lyng (2021). A 4-Gene Signature of CDKN1, FDXR, SESN1 and PCNA Radiation Biomarkers for Prediction of Patient Radiosensitivity. IJMS, https://doi.org/10.3390/ijms221910607.

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A. Keogan, T.N.Q. Nguyen, J.J. Phelan, N. O'Farrell, N. Lynam-Lennon, B. Doyle, D. O'Toole, J.V. Reynolds, J. O'Sullivan, A.D. Meade (2021). Chemical imaging and machine learning for sub-classification of oesophageal tissue histology. Trans. Bioph., https://doi.org/10.1002/tbio.202100004.

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M. Beshr, G. Amarandei, A.D. Meade, R.E. Palmer, S. Murphy (2021). Application of scanning probe energy loss spectroscopy to SERS-active metal nanostructures. J. Phys.: Conf. Ser. 1866 012006, https://iopscience.iop.org/article/10.1088/1742-6596/1866/1/012006.

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N. Chaudhary, T.N.Q. Nguyen, M. Ahmad, R. Harrington, C.A. Jefferies, G.Kearns, A.D. Meade, C. Wynne (2021). A Spectroscopic Diagnostic for Rheumatoid Arthritis using Liquid Biopsies. Clin. Spec., https://doi.org/10.1016/j.clispe.2021.100009.

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Simonetta Pazzaglia, Barbara Tanno, Francesca Antonelli, Paola Giardullo, Gabriele Babini, Prabal Subedi, Omid Azimzadeh, Zohaib N. Khan, Kateryna Oleksenko, Fabian Metzger, Christine von Toerne, Damien Traynor, Dinesh Medipally, Aidan D. Meade, Munira Kadhim, Fiona M. Lyng, Soile Tapio, Anna Saran, Mariateresa Mancuso (2021). Out-of-field hippocampus from partial-body irradiated mice displays changes in multi-omics profile and defects in neurogenesis. IJMS, https://doi.org/10.3390/ijms22084290.

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N. Chaudhary, T.N.Q. Nguyen, A. Maguire, C. Wynne, A.D. Meade (2021). Comparison of sample preparation methodologies towards optimisation of Raman spectroscopy for peripheral blood mononuclear cells. Anal. Methods, https://doi.org/10.1039/D0AY02040K.

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S. Tuncay Cagatay, A. Mayah, M. Mancuso, P. Giardullo, S. Pazzaglia, A. Saran, A. Daniel, D. Traynor, A.D. Meade, F. Lyng, S. Tapio, M. Khadim (2020). Phenotypic and Functional Characteristics of Exosomes Derived from Irradiated Mouse Organs and Their Role in the Mechanisms Driving Non-Targeted Effects. IJMS, https://doi.org/10.3390/ijms21218389.

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N. Chaudhary, T.N.Q. Nguyen, D. Cullen, A.D. Meade, C. Wynne (2020). Discrimination of immune cell activation using Raman micro-spectroscopy in an in-vitro & ex-vivo model. Spec. Acta Part A: Mol. Biomolec. Spec., https://doi.org/10.1016/j.saa.2020.119118.

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T.N.Q. Nguyen, A. Maguire, C. Mooney, N. Jackson, N. Lynam-Lennon, V. Weldon, C. Muldoon, A.A. Maguire, D. O'Toole, N. Ravi, J.V. Reynolds, J. O'Sullivan, A.D. Meade (2020). Prediction of pathological response to neo‐adjuvant chemoradiotherapy for oesophageal cancer using vibrational spectroscopy. Translational Biophotonics, https://doi.org/10.1002/tbio.202000014.

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D.K.R Medipally, T.N.Q. Nguyen, J. Bryant, V. Untereiner, G.D. Sockalingum, D. Cullen, S. Noone, M. Bradshaw, M. Finn, M. Dunne, A.M. Shannon, J. Armstrong, F.M. Lyng, A.D. Meade (2020). Vibrational spectroscopy of liquid biopsies for prostate cancer diagnosis. Therapeutic Advances in Medical Oncology, https://doi.org/10.1177/1758835920918499.

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D. Cullen, J. Bryant, A. Maguire, D.K.R. Medipally, B. McClean, L. Shields, E. Noone, S. Bradshaw, M. Finn, M. Dunne, A.M. Shannon, J. Armstrong, O. Howe, A.D. Meade, F.M. Lyng (2020). Raman spectroscopy of lymphocytes for the identification of prostate cancer patients with late radiation toxicity following radiotherapy. Translational Biophotonics, https://doi.org/10.1002/tbio.201900035.

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Dinesh K. R. Medipally, Daniel Cullen, Valerie Untereiner, Jane Bryant, Ganesh D. Sockalingum, Thi N. Q. Nguyen, Emma Noone, Shirley Bradshaw, Marie Finn, Mary Dunne, Aoife M. Shannon, John Armstrong, Aidan D. Meade, Fiona M. Lyng (2020). Effect of hemolysis on Fourier transform infrared and Raman spectra of blood plasma. Journal of Biophotonics, (13), 7, https://doi.org/10.1002/jbio.201960173.

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Jane Bryant, Lisa White, Natasha Coen, Laura Shields, Brendan McClean, Aidan D. Meade, Fiona M. Lyng, Orla Howe (2020). MicroRNA Analysis of ATM-Deficient Cells Indicate PTEN and CCDN1 as Potential Biomarkers of Radiation Response. Radiation Research, (193), 6, pp. 520–530, https://doi.org/10.1667/RR15462.1.

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Neha Chaudhary, Claire Wynne, Aidan D. Meade (2020). A review of applications of Raman spectroscopy in immunology. Biomedical Spectroscopy and Imaging, (9), 1-2, pp. 23–31, https://doi.org/10.3233/bsi-200198.

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Lisa White, Laura Shields, Orla Howe, Isabel Vega Carrascal, Adrian Maguire, Aidan Meade, Brendan McClean, Fiona M Lyng (2020). A Comparison of Radiobiological Response in Cells Exposed to Low LET Radiation with Different Beam Energies. Radiat Environ Med, (9), 1, pp. 1–6.

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D. O'Dea, M. Bongiovanni, G.P. Sykiotis, P.G. Ziros, A.D. Meade, F.M. Lyng, A. Malkin (2019). Raman spectroscopy for the preoperative diagnosis of thyroid cancer and its subtypes: An in-vitro proof-of-concept study. Cytopathology, (30), 1, https://doi.org/10.1111/cyt.12636.

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D K R Medipally, T N Q Nguyen, J Bryant, V Untereiner, G D Sockalingum, D Cullen, E Noone, S Bradshaw, M Finn, M Dunne, A M Shannon, J Armstrong, F M Lyng, A D Meade (2019). Monitoring Radiotherapeutic response in prostate cancer patients using high throughput FTIR Spectroscopy of Liquid Biopsies. Cancers, (11), 7, https://doi.org/10.3390/cancers11070925.

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F.M. Lyng, D. Traynor, T.N.Q. Nguyen, A.D. Meade, F. Rakib, R. Al-Saady, E. Goormaghtigh, K. Al-Saad, M.H. Ali (2019). Discrimination of breast cancer from benign tumours using Raman spectroscopy. PLoS ONE, (14), 2, https://doi.org/10.1371/journal.pone.0212376.

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Aidan Meade, Frances Eileen Quigley, George Amarandei (2018). Imaging of biological tissue. PCT/EP2019/086398, https://patents.google.com/patent/WO2020127795A1/.

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A.D. Meade, A. Maguire, J. Bryant, D. Cullen, D. Medipally, L. White, B. McClean, L. Shields, J. Armstrong, M. Dunne, E. Noone, S. Bradshaw, M. Finn, A.M. Shannon, O. Howe, F.M. Lyng (2018). Prediction of DNA damage and G2 chromosomal radio-sensitivity ex vivo in peripheral blood mononuclear cells with label-free Raman micro-spectroscopy. International Journal of Radiation Biology, (95), 1, https://doi.org/10.1080/09553002.2018.1451006.

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E. Ainsbury, C. Badie, S. Barnard, G. Manning, J. Moquet, M. Abend, A.C. Antunes, L. Barrios, C. Bassinet, C. Beinke, E. Bortolin, L. Bossin, C. Bricknell, K. Brzoska, I. Buraczewska, C.H. Castano, Z. Cemusova, M. Christiansson, S.M. Cordero, G. Cosler, S.D. Monaca, F. Desangles, M. Discher, I. Dominguez, S. Doucha-Senf, J. Eakins, P. Fattibene, S. Filippi, M. Frenzel, D. Georgieva, E. Gregoire, K. Guogyte, V. Hadjidekova, L. Hadjiiska, R. Hristova, M. Karakosta, E. Kis, R. Kriehuber, J. Lee, D. Lloyd, K. Lumniczky, F. Lyng, E. Macaeva, M. Majewski, S. Vanda Martins, S.W.S. McKeever, A. Meade, D. Medipally, R. Meschini, R. M'kacher, O.M. Gil, A. Montero, M. Moreno, M. Noditi, U. Oestreicher, D. Oskamp, F. Palitti, V. Palma, G. Pantelias, J. Pateux, C. Patrono, G. Pepe, M. Port, M.J. Prieto, M.C. Quattrini, R. Quintens, M. Ricoul, L. Roy, L. Sabatier, N. Sebastia, S. Sholom, S. Sommer, A. Staynova, S. Strunz, G. Terzoudi, A. Testa, F. Trompier, M. Valente, O.V. Hoey, I. Veronese, A. Wojcik, C. Woda (2017). Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans–joint RENEB and EURADOS inter-laboratory comparisons. International Journal of Radiation Biology, (93), 1, https://doi.org/10.1080/09553002.2016.1206233.

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O. Ibrahim, A. Maguire, A.D. Meade, S. Flint, M. Toner, H.J. Byrne, F.M. Lyng (2017). Improved protocols for pre-processing Raman spectra of formalin fixed paraffin preserved tissue sections. Analytical Methods, (9), 32, https://doi.org/10.1039/c6ay03308c.

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Dinesh K.R. Medipally, Adrian Maguire, Jane Bryant, John Armstrong, Mary Dunne, Marie Finn, Fiona M. Lyng, Aidan D. Meade (2017). Development of a high throughput (HT) Raman spectroscopy method for rapid screening of liquid blood plasma from prostate cancer patients. Analyst, (142), 8, pp. 1216–1226, https://doi.org/10.1039/c6an02100j.

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A.D. Meade, O. Howe, V. Unterreiner, G.D. Sockalingum, H.J. Byrne, F.M. Lyng (2016). Vibrational spectroscopy in sensing radiobiological effects: Analyses of targeted and non-targeted effects in human keratinocytes. Faraday Discussions, (187), https://doi.org/10.1039/c5fd00208g.

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M.J. Baker, R. Goodacre, C. Sammon, M.P. Marques, P. Gardner, W. Tipping, J. Sule-Suso, B. Wood, H.J. Byrne, M. Hermes, P. Matousek, C.J. Campbell, S. El-Mashtoly, J. Frost, C. Phillips, M. Diem, A. Kohler, K. Lau, S. Kazarian, W. Petrich, G. Lloyd, I. Delfino, G. Cinque, M. Isabelle, N. Stone, C. Kendall, L. Jamieson, D. Perez-Guaita, L. Clark, K. Gerwert, I. Notingher, L. Quaroni, R. Bhargava, A. Meade, F. Lyng (2016). Single cell analysis/data handling: General discussion. Faraday Discussions, (187), https://doi.org/10.1039/C6FD90012G.

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I.R. Ramos, A.D. Meade, O. Ibrahim, H.J. Byrne, M. McMenamin, M. McKenna, A. Malkin, F.M. Lyng (2016). Raman spectroscopy for cytopathology of exfoliated cervical cells. Faraday Discussions, (187), https://doi.org/10.1039/c5fd00197h.

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Aidan Meade, Aaron MacRaighne, Elizabeth Gregan, Izabela Naydenova, Francis Pedreschi (2015). Exploring Technology Enhanced Instruction and Assessment in the Advanced Physics Laboratory. DIT Teaching Fellowship Reports 2014-2015.

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Lisa White, Fiona Lyng, Aidan D. Meade, Orla Howe (2015). Predictive Biomarkers of Cellular Radiosensitivity for Clinical Radiotherapy Treatment. Thesis submitted to the Technological University Dublin for the award of PhD, July 2016.

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Fiona Lyng, Adrian Maguire, Aidan Meade, Isabel VEGA Carrascal, Lisa White, Orla Howe (2015). Prediction of therapeutic response using vibrational spectroscopy. US20180372710A1, https://patents.google.com/patent/US20180372710A1/en.

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A. Maguire, I. Vega-Carrascal, J. Bryant, L. White, O. Howe, F.M. Lyng, A.D. Meade (2015). Competitive evaluation of data mining algorithms for use in classification of leukocyte subtypes with Raman microspectroscopy. Analyst, (140), 7, https://doi.org/10.1039/c4an01887g.

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A. Maguire, I. Vegacarrascal, L. White, B. McClean, O. Howe, F.M. Lyng, A.D. Meade (2015). Analyses of ionizing radiation effects in Vitro in peripheral blood lymphocytes with Raman spectroscopy. Radiation Research, (183), 4, https://doi.org/10.1667/RR13891.1.

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H.J. Byrne, K.M. Ostrowska, H. Nawaz, J. Dorney, A.D. Meade, F. Bonnier, F.M. Lyng (2014). Vibrational spectroscopy: Disease diagnostics and beyond. Optical Spectroscopy and Computational Methods in Biology and Medicine, https://doi.org/10.1007/978-94-007-7832-0_13.

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A.D. Meade, C. Clarke, H.J. Byrne, F.M. Lyng (2014). Selection of preprocessing methodology for multivariate regression of cellular FTIR and Raman spectra in radiobiological analyses. IEEE BIBM, https://doi.org/10.1109/BIBM.2014.6999164.

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H. Nawaz, A. Garcia, A.D. Meade, F.M. Lyng, H.J. Byrne (2013). Raman micro spectroscopy study of the interaction of vincristine with A549 cells supported by expression analysis of bcl-2 protein. Analyst, (138), 20, https://doi.org/10.1039/c3an00975k.

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K.W.C. Poon, F.M. Lyng, P. Knief, O. Howe, A.D. Meade, J.F. Curtin, H.J. Byrne, J. Vaughan (2012). Quantitative reagent-free detection of fibrinogen levels in human blood plasma using Raman spectroscopy. Analyst, (137), 8, https://doi.org/10.1039/c2an35042d.

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A.A. Shvedova, A.A. Kapralov, W.H. Feng, E.R. Kisin, A.R. Murray, R.R. Mercer, C.M. St. Croix, M.A. Lang, S.C. Watkins, N.V. Konduru, B.L. Allen, J. Conroy, G.P. Kotchey, B.M. Mohamed, A.D. Meade, Y. Volkov, A. Star, B. Fadeel, V.E. Kagan (2012). Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice. PLoS ONE, (7), 3, https://doi.org/10.1371/journal.pone.0030923.

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F. Bonnier, A. Mehmood, P. Knief, A.D. Meade, W. Hornebeck, H. Lambkin, K. Flynn, V. McDonagh, C. Healy, T.C. Lee, F.M. Lyng, H.J. Byrne (2011). In vitro analysis of immersed human tissues by Raman microspectroscopy. Journal of Raman Spectroscopy, (42), 5, https://doi.org/10.1002/jrs.2825.

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K.M. Ostrowska, A. Garcia, A.D. Meade, A. Malkin, I. Okewumi, J.J. O'Leary, C. Martin, H.J. Byrne, F.M. Lyng (2011). Correlation of p16INK4A expression and HPV copy number with cellular FTIR spectroscopic signatures of cervical cancer cells. Analyst, (136), 7, https://doi.org/10.1039/c0an00910e.

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H. Nawaz, F. Bonnier, A.D. Meade, F.M. Lyng, H.J. Byrne (2011). Comparison of subcellular responses for the evaluation and prediction of the chemotherapeutic response to cisplatin in lung adenocarcinoma using Raman spectroscopy. Analyst, (136), 12, https://doi.org/10.1039/c1an15104e.

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F. Bonnier, P. Knief, A.D. Meade, J. Dorney, K. Bhattacharya, F.M. Lyng, H.J. Byrne (2011). Collagen matrices as an improved model for in vitro study of live cells using Raman microspectroscopy. SPIE, European Conference on Biomedical Optics, (8087), https://doi.org/10.1117/12.889872.

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F. Bonnier, A.D. Meade, P. Knief, K. Bhattacharya, F.M. Lyng, H.J. Byrne (2010). Study of live cells grown on three dimensional collagen gels using Raman microspectroscopy. AIP Conference Proceedings, (1267), https://doi.org/10.1063/1.3482599.

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F. Bonnier, A.D. Meade, S. Merzha, P. Knief, K. Bhattacharya, F.M. Lyng, H.J. Byrne (2010). Three dimensional collagen gels as a cell culture matrix for the study of live cells by Raman spectroscopy. Analyst, (135), 7, https://doi.org/10.1039/c0an00060d.

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A.D. Meade, C. Clarke, F. Draux, G.D. Sockalingum, M. Manfait, F.M. Lyng, H.J. Byrne (2010). Studies of chemical fixation effects in human cell lines using Raman microspectroscopy. Analytical and Bioanalytical Chemistry, (396), 5, https://doi.org/10.1007/s00216-009-3411-7.

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A.D. Meade, H.J. Byrne, F.M. Lyng (2010). Spectroscopic and chemometric approaches to radiobiological analyses. Mutation Research - Reviews in Mutation Research, (704), 1-3, https://doi.org/10.1016/j.mrrev.2010.01.010.

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K.M. Ostrowska, A. Malkin, A. Meade, J. O'Leary, C. Martin, C. Spillane, H.J. Byrne, F.M. Lyng (2010). Investigation of the influence of high-risk human papillomavirus on the biochemical composition of cervical cancer cells using vibrational spectroscopy. Analyst, (135), 12, https://doi.org/10.1039/c0an00571a.

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F. Bonnier, P. Knief, B. Lim, A.D. Meade, J. Dorney, K. Bhattacharya, F.M. Lyng, H.J. Byrne (2010). Imaging live cells grown on a three dimensional collagen matrix using Raman microspectroscopy. Analyst, (135), 12, https://doi.org/10.1039/c0an00539h.

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A.D. Meade, C. Clarke, H.J. Byrne, F.M. Lyng (2010). Fourier transform infrared microspectroscopy and multivariate methods for radiobiological dosimetry. Radiation Research, (173), 2, https://doi.org/10.1667/RR1836.1.

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H. Nawaz, F. Bonnier, P. Knief, O. Howe, F.M. Lyng, A.D. Meade, H.J. Byrne (2010). Evaluation of the potential of Raman microspectroscopy for prediction of chemotherapeutic response to cisplatin in lung adenocarcinoma. Analyst, (135), 12, https://doi.org/10.1039/c0an00541j.

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A.D. Meade, C. Clarke, F. Bonnier, K. Poon, A. Garcia, P. Knief, K. Ostrowska, L. Salford, H. Nawaz, F.M. Lyng, H.J. Byrne (2009). Functional and pathological analysis of biological systems using vibrational spectroscopy with chemometric and heuristic approaches. IEEE WHISPERS Conference, https://doi.org/10.1109/WHISPERS.2009.5288989.

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P. Knief, C. Clarke, E. Herzog, M. Davoren, F.M. Lyng, A.D. Meade, H.J. Byrne (2009). Raman spectroscopy - A potential platform for the rapid measurement of carbon nanotube-induced cytotoxicity. Analyst, (134), 6, https://doi.org/10.1039/b821393c.

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F.M. Lyng, E.O. Faolain, J. Conroy, A.D. Meade, P. Knief, B. Duffy, M.B. Hunter, J.M. Byrne, P. Kelehan, H.J. Byrne (2007). Vibrational spectroscopy for cervical cancer pathology, from biochemical analysis to diagnostic tool. Experimental and Molecular Pathology, (82), 2, https://doi.org/10.1016/j.yexmp.2007.01.001.

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A.D. Meade, F.M. Lyng, P. Knief, H.J. Byrne (2007). Growth substrate induced functional changes elucidated by FTIR and Raman spectroscopy in in-vitro cultured human keratinocytes. Analytical and Bioanalytical Chemistry, (387), 5, https://doi.org/10.1007/s00216-006-0876-5.

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A.D. Meade, H.J. Byrne, F.M. Lyng (2005). Correlation of spectroscopic and biochemical assays post-ionising radiation exposure in human skin cell analogues. SPIE Opto Ireland 2005, (5826), https://doi.org/10.1117/12.611450.

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Mohamed Beshr, E Dexter, Paul E Tierney, AD Meade, Shane Murphy, George Amarandei (0001). Towards plasmon mapping of SERS-active Ag dewetted nanostructures using SPELS.. J. Phys. Conf.,2172, 012012, https://iopscience.iop.org/article/10.1088/1742-6596/2172/1/012012/meta.

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